About-LOTUS

Our Datasites

About LOTUS

LOTUS is comprised of five US integrated healthcare systems representing diverse populations and communities. The research team includes investigators in each healthcare system as well as Harvard and University of Michigan.

Across the Colorado region, Kaiser Permanente Colorado (KPCO) serves approximately 660,000 members living in the Denver/Boulder metropolitan area and Colorado front-range communities.

Adult Health System Members Characteristics (Jan 2010-Sept 2021)

Female Male	52% 48%
Average Age	58 yrs.
American Indian/Alaska Native Asian/Pacific Islander Hispanic Non-Hispanic Black Non-Hispanic White Multiple/Another Race/Ethnicity Unknown	1% 4% 13% 4% 61% 3% 14%

Kaiser Permanente Colorado

Kaiser Permanente Hawaii is a comprehensive healthcare system comprised of three entities: Kaiser Foundation Health Plan, Kaiser Foundation Hospital, and Hawaii Permanente Medical Group. We have one hospital (Moanlua Medical Center) and 18 clinics on four islands across Hawaii.

Adult Health System Members Characteristics (Jan 2010-Sept 2021)

Female Male	51% 49%
Average Age	58 yrs.
American Indian/Alaska Native Asian/Pacific Islander Hispanic Non-Hispanic Black Non-Hispanic White Multiple/Another Race/Ethnicity Unknown	1% 48% 4% 1% 26% 0% 19%

Kaiser Permanente Hawaii

The Henry Ford Health System (HFHS) is a comprehensive healthcare system that serves five regions across Michigan. The five regions include a) Detroit and western Wayne County, b) Southern Wayne County, c) Northwest-Oakland County, d) Northeast - Macomb County. The HFHS includes five hospitals, the Henry Ford Medical Group, the Health Alliance Plan, and more than 35 clinics and satellite centers.

Adult Health System Members Characteristics (Jan 2010-Sept 2021)

Female Male	55% 45%
Average Age	61 yrs.
American Indian/Alaska Native Asian/Pacific Islander Hispanic Non-Hispanic Black Non-Hispanic White Multiple/Another Race/Ethnicity Unknown	<1% 3% 3% 24% 59% 2% 9%

Henry Ford Health System in Metro Detroit

Marshfield Clinic Health System (MCHS) is the largest private group practice in Wisconsin, with 7 hospitals and 55 clinical locations in 34 communities across the region. MCHS sees approximately 330,000 patients annually, of which approximately 220,000 are enrolled in the Security Health Plan.

Adult Health System Members Characteristics (Jan 2010-Sept 2021)

Female Male	53% 47%
Average Age	63 yrs.
American Indian/Alaska Native Asian/Pacific Islander Hispanic Non-Hispanic Black Non-Hispanic White Multiple/Another Race/Ethnicity Unknown	1% 1% 2% <1% 88% 1% 8%

Marshfield Clinic Health System in Wisconsin

Penn Medicine is comprised of two main entities, the University of Pennsylvania Health System and the Perelman School of Medicine, governed by a single corporate structure. Penn Medicine is comprised of a diverse network of hospitals and two integrated networks of community-based practices. The six hospitals are the Hospital of the University of Pennsylvania (HUP), Penn Presbyterian Medical Center (PPMC), Pennsylvania Hospital (PAH), Chester County Hospital (CCH), Lancaster General Hospital (LGH), and most recently Princeton Medical Center (PMC).

Adult Health System Members Characteristics (Jan 2010-Sept 2021)

Female Male	57% 43%
Average Age	60 yrs.
American Indian/Alaska Native Asian/Pacific Islander Hispanic Non-Hispanic Black Non-Hispanic White Multiple/Another Race/Ethnicity Unknown	<1% 6% 4% 21% 64% 3% 4%

University of Pennsylvania Health System

Lung Cancer Screening Optimization in the U.S.

LOTUS data as of 2021

Cohort Size (ages 35-89)

COMPLETED 1 OR MORE LCS LDCT

unique Healthcare Systems

LOTUS Patient Population

2014-2021 (Estimated) Aggregate Characteristics

Sex

Lung cancer screening may have different effects in men and women; our consortium is well-suited to evaluate these potential differences.

RACE AND ETHNICITY

Lung cancer incidence and mortality are higher in groups that are often medically underserved, including Non-Hispanic Black populations. Thus, it is important that lung cancer screening reach diverse populations, so that lung cancer related health disparities are reduced and not worsened through lung cancer screening programs.

The LOTUS consortium covers a diverse population, so that we can study lung cancer screening uptake and impacts in different groups and identify ways to optimize lung cancer screening to benefit diverse populations.

AGE

Increasing age is a risk factor for lung cancer, and current guidelines use age as one of the criteria for who should receive lung cancer screening. Understanding the benefits and risks of lung cancer screening at different ages is important so that policy-makers, patients, and doctors can make informed decisions about who should initiate lung cancer screening.